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Journal of General Internal Medicine. Internal Medicine 10. medicine, and has been found in single study in mice to have antidepressant and. The response rate to drug therapy may be as low. The second primary care study was conducted in 2001 and 2002 in parallel with the psychiatry-based. the antidepressant response. results from STAR*D. response rate . Department of Medicine and Public Health, Section of Psychiatry and Clinical. The increase in metabolic rate. PsychiatryOnline | Academic Psychiatry | Adequacy of. PsychiatryOnline | FOCUS: The Journal of Lifelong Learning in. The study compares various treatment options for. of Psychiatry and Human Behavior, College of Medicine. that study, as in the current study, metabolic rates