Generic Zovirax (Acyclovir Cream) is a guanosine analogue antiviral drug. Generic Zovirax (Acyclovir Cream) is used to treat herpes simplex virus infections. Acyclovir Cream is also used in the treatment of herpes zoster (shingles). Generic Zovirax is used to treat cold sores on lips and face. Acyclovir Cream does not cure herpes but relieves pain and may help to clear infection faster.